Skip to main content
SpringerLink
Log in

Cell-cell and cell-matrix adhesion molecules in human heart and lung transplants

  • Part I: Extracellular Matrix and Cardiocyte Interaction
  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Abstract

The interaction of immune cells with endothelial and target cells and extracellular matrix in human organ transplants is regulated by a number of receptor-ligand molecules. The molecules mediating intercellular adhesion and activation are classified as integrin, immunoglobulin and selectin families. In the present study the patterns of their cellular expression in human heart and lung transplants are described in normal state and during transplant rejection. The results reveal an organ specific regulation of the different adhesion molecules during transplant rejection. Specific differences were noted in the endothelial expression of vascular ligand molecules in the vascular segments of heart and lung transplants, especially in the lung capillaries. Cell type specific patterns of intercellular and cell-matrix adhesion molecules as their ligands were found in different states of graft rejection. Intravascular and interstitial differences in the expression patterns of leukocyte adhesion receptors support a concept of their stepwise function during graft infiltration. The implications for the organ specific appearance of inflammatory reactions in human heart and lung transplants as for immunosuppressive therapy are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Steinhoff G, Behrend M, Haverich A: Signs of endothelial inflammation in human heart allograft biopsies. Eur Heart J 12: 141–143, 1990

    Google Scholar 

  2. Springer TA: Adhesion receptors of the immune system. Nature 346: 425–434, 1990

    PubMed  Google Scholar 

  3. Hogg N, Harvey J, Cabanas C, Landis RC: Control of leukocyte integrin activation. Am Rev Respir Dis 148: 55–9, 1993

    Google Scholar 

  4. Springer TA, Lasky TA: Sticky sugars for selectins. Nature 349: 196, 1991

    PubMed  Google Scholar 

  5. Hynes RO: Integrins: Versatility, modulation and signaling in cell adhesion. Cell 69: 11–25, 1992

    PubMed  Google Scholar 

  6. Steinhoff G (ed.): Cell adhesion molecules in human organ transplants. R. G. Landes Company, Austin. 1993, pp 1–110

    Google Scholar 

  7. Steinhoff G, Behrend M, Schrader B, Duijvestijn AM, Wonigeit K: Experession Patterns of Leucocyte Adhesion Ligand Molecules on Human Liver Endothelia: Lack of ELAM-1 and CD62 Inducibility on Sinusoidal Endothelia and Distinct Distribution of VCAM-1, ICAM-1, ICAM-2 and LFA-3. A J Path 142: 481–488, 1993

    Google Scholar 

  8. Steinhoff G, Behrend M, Schrader B, Pichlmayr R: Intercellular Immune Adhesion Molecules in Human Liver Transplants—Overview on Expression Patterns of Leukocyte Receptor and Ligand Molecules. Hepatology 18(2): 440–453, 1993

    PubMed  Google Scholar 

  9. Haverich A, Hirt SW, Wahlers T, Schäfers HJ, Zink C, Borst HG: Functional results after lung retransplatation. J Heart Lung Transpl 13: 48–55, 1994

    Google Scholar 

  10. Steinhoff G, Wonigeit K, Schäfers HJ, Haverich A: Sequential analysis of monomorphic and polymorphic major histocompatibility complex antigen expression in human heart allograft biopsy specimens. J Heart Transpl 8: 360–370, 1989

    Google Scholar 

  11. Taylor PM, Rose ML, Yacoub MH: Expression of MHC antigens in normal human lung and transplanted lungs with obliterative bronchiolitis. Transplantation 48: 506–510, 1989

    PubMed  Google Scholar 

  12. Clavien PA, Harvey PRC, Strasberg SM: Preservation and reperfusion injuries in liver allografts. Transplantation 53: 957–978, 1992

    PubMed  Google Scholar 

  13. Marzi I, Walcher F, Menger M, Bühren V, Harbauer G, Trentz O: Microcirculatory disturbances and leucocyte adherence in transplanted livers after cold storage in euro-Collins, UW and HTK solutions. Transplant Int 4: 45–50, 1991

    Google Scholar 

  14. Shackleton CR, Ettinger SL, McLoughlin MG, Scudamore CH, Miller RR, Keown PA: Effect of recovery from ischemic injury on class I and class II MHC antigen expression. Transplantation 49: 641–644, 1990

    PubMed  Google Scholar 

  15. Howard TK, Klintmalm GB, Cofer JB, Huberg BS, Goldstein RM, Gonwa TA: The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation 49: 103–107, 1990

    PubMed  Google Scholar 

  16. Horgan MJ, Wright SD, Malik AB: Antibody against leukocyte integrin (CD18) prevents reperfusion-induced lung vascular injury. Am J Physiol 259: 315–319, 1990

    Google Scholar 

  17. Simpson P, Todd III JRF, Fantone JC, Mickelson JM, Griffin JD, Lucchesi BR: Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mol, anti-CD11b) that inhibits leukocyte adhesion. J Clin Invest 81: 624–629, 1988

    PubMed  Google Scholar 

  18. Simpson PJ, Michalson J, Fatane JC, Gallagher KP, Lucchesi BR: Reduction of experimental canine myocardial infarct size with prostaglandin E1: inhibition of neutrophil migration and activation. J Pharmacol Exp Ther 244 (2): 619–624, 1988

    PubMed  Google Scholar 

  19. Ferran C, Peuchmaur M, Desruennes M, Ghoussoub JJ, Cabrol A, Brousse N, Cabrol C, Bach JF, Chatenoud L: Implications of de novo ELAM-1 and VCAM-1 expression in human cardiac allograft rejection. Transplantation 55: 605–609, 1993

    PubMed  Google Scholar 

  20. Lindbohm L, Xie X, Raud, Hedqvist P: Chemoattractant-induced leukocyte adhesion to vascular endotheliumin vivo is critically dependent on initial leukocyte rolling. Acta Physiol Scand 146: 415–421, 1992

    PubMed  Google Scholar 

  21. Dalton SL, Marcantonio EE, Assoian RK: Cell attachment controls fibronectin and a5\1 integrin levels in fibroblasts. Implications for anchorage dependent and-independent growth. J Biol Chem 267: 8186–8191, 1992

    PubMed  Google Scholar 

  22. Seth R, Raymond FD, Makgoba MW: Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet 338: 83–84, 1991

    PubMed  Google Scholar 

  23. Haynes BF, Telen MJ, Hale LP, Denning SM: CD44 — a molecule involved in leukocyte adherence and T-cell activation. Immunol Today 10: 423–428, 1989

    PubMed  Google Scholar 

  24. Cosimi AB, Conti D, Delmonico FL, Preffer FI, Wee S-L, Rothlein R, Faanes R, Colvin R:In vivo effects of monoclonal antibody to ICAM-1 (CD54) in non-human primates with renal allografts. J Immunol 144: 4604–4612, 1990

    PubMed  Google Scholar 

  25. Flavin T, Ivens K, Rothlein R, Faanes R, Clayberger C, Billingham M, Starnes VA: Monoclonal antibodies against Intercellular Adhesion Molecule 1 prolong cardiac allograft survival in cynomolgus monkeys. Transplant Proc 23: 533–534, 1991

    PubMed  Google Scholar 

  26. Heagy W, Waltenbaugh C, Martz E: Potent ability of anti LFA-1 monoclonal antibody to prolong allograft survival. Transplantation 37: 520–523, 984

  27. Kaslovsky RA, Horgan MJ, Lum H, McCandless BK, Giboa N, Wright SD, Malik AB: Pulmonary edema induced by phagocytosing neutrophils — protective effect of monoclonal antibody against phagocyte CD18 Integrin. Circ Res 67: 795–802, 1990

    PubMed  Google Scholar 

  28. Paul LC, Davidoff A, Paul DW, Bendiktsson H, Issekutz TB: Monoclonal antibodies against LFA-1 and VLA-4 inhibit graft vasculitis in rat cardiac allografts. Transplant Proc 25: 813, 1993

    PubMed  Google Scholar 

  29. Orosz CG, Ohye RG, Pelletier RP, Van Buskirk AM, Huang E, Morgan C, Kincade PW, Ferguson RM: Treatment with anti-vascular cell adhesion molecule 1 monoclonal antibody induces long-term murine cardiac allograft acceptance. Transplantation 56(2): 453–60, 1993

    PubMed  Google Scholar 

  30. Mulligan MS, Paulson JC, De Frees S, Zheng ZL, Lowe JB, Ward PA: Protective effects of oligosaccharides in P-selectin-dependent lung injury. Nature 364: 149–51, 1993

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiovascular Surgery, Christian Albrechts University of Kiel, 24105, Kiel, Germany

    Gustav Steinhoff & Axel Haverich

Authors
  1. Gustav Steinhoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Axel Haverich
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Steinhoff, G., Haverich, A. Cell-cell and cell-matrix adhesion molecules in human heart and lung transplants. Mol Cell Biochem 147, 21–27 (1995). https://doi.org/10.1007/BF00944779

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00944779

Key words

Search

Navigation