Abstract
A glucose tolerance test was performed on dogs by injecting glucose intravenously and measuring the plasma glucose and insulin concentrations versus time. Various analytical and computational techniques were utilized to fit the data to a minimal model and to estimate the parameters of the blood glucose regulation process. A relatively good fit was obtained in spite of the rather simple model.
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Animal experiments were funded by the National Institute of Health Grant No. AM-17236 awarded to Dr. R. N. Bergman at U.S.C.
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Bergman, R.N., Kalaba, R.E. & Spingarn, K. Optimizing inputs for diagnosis of diabetes. I. Fitting a minimal model to data. J Optim Theory Appl 20, 47–63 (1976). https://doi.org/10.1007/BF00933347
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DOI: https://doi.org/10.1007/BF00933347