Abstract
Gonadectomized male laboratory rats were given 0.06 mg/kg estradiol benzoate daily for 14 days before being inoculated with 50 third-stage larvae ofParastrongylus malaysiensis. Hormone treatment was continued until the rats were killed. The numbers of larvae in the brain and of adult worms in the pulmonary area of the rats were determined every 7 days after the inoculation. It was found that the rats treated daily with estradiol benzoate had significantly and consistently higher numbers of larvae and adult worms as compared with the controls. The number of total leukocytes increased significantly after the rats were infected. The results show that estradiol-treated rats become susceptible toP. malaysiensis infection, which may indicate that the immunosuppressive effects of testosterone observed in earlier studies may partly be caused by estradiol that was peripherally aromatized from testosterone.
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Ahmad RA, Kamis AB, Badrul-Munir MZ (1992)Parastrongylus malaysiensis infection in rats: effects of estradiol. Trop Biomed 9:45–48
Benten WPM, Wunderlich F, Mossmann H (1992)Plasmodium chabaudi: estradiol suppresses acquiring, but not once-acquired immunity. Exp Parasitol 75:240–247
Bhaibulaya M, Cross JH (1971)Angiostrongylus malaysiensis (Nematoda: Metastrongylidae), a new species of rat lungworm from Malaysia. Southeast Asian J Trop Med Public Health 2:527–533
Danel L, Souweine G, Monier JC, Saez S (1983) Specific estrogen binding sites in human lymphoid cells and thymic cells. J Steroid Biochem 18:559–563
Griffin JE, Wilson JD (1985) Disorders of the testis and male reproductive tract. In: Wilson JD, Foster DW (eds) Williams textbook of endocrinology. W.B. Saunders, Philadelphia, pp 259–311
Grossman CJ (1989) Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis. J Steroid Biochem 34:241–151
Grossman CJ, Sholiton LJ, Roselle G (1982) Estradiol regulation of thymic lymphocytes function in the rats: mediation by serum thymic factors. J Steroid Biochem 16:683–693
Hodgins MB (1989) Peripheral oestrogen synthesis in man: its regulation and possible physiological significance. J Endocrinol 121:1–3
Kamis AB, Chen KH (1991)Plasmodium berghei infection in mice: effects of estradiol. Mosquito-Borne Dis Bull 8:45–47
Kamis AB, Ahmad RA, Badrul-Munir MZ (1992) Worm burden and leukocyte response inAngiostrongylus malaysiensis-infected rats: the influence of testosterone. Parasitol Res 78:388–391
Lim BL (1977) Studies of life cycle and transmission ofAngiostrongylus malaysiensis Bhaibulaya and Cross, 1971 in Peninsular Malaysia. PhD Thesis, Universiti Sains Malaysia
Lim BL, Ramachandran CP (1979) Ecological studies onAngiostrongylus malaysiensis (Nematoda: Metastrongylidae) in Malaysia. In: Cross JH (ed). Studies on angiostrongyliasis in Eastern Asia and Australia. United States Naval Medical Research Unit, Taipei, pp 26–48
Luebke RW, Luster MI, Dean JH, Hayes HT (1984) Altered host resistance toTrichinella spiralis infection following subchronic exposure to diethylstilbestrol. Int J Immunopharmacol 6:609–618
Luster MI, Hayes HT, Korach K, Tucker AN, Dean JH, Greenlee WF, Boorman GA (1984) Estrogen immunosuppression is regulated through estrogenic responses in the thymus. J Immunol 133:110–116
Molan AL, Brain PF, James BL (1984) The retention and egg production inMicrophallus pygmaeus (Levinsen 1881) (Digenea: Microphallidae) in gonadectomized and hormone-treated male mice. Parasitol Res 70:627–636
Schuurs AHWM, Verheul HAM (1990) Effects of gender and sex steroids on the immune response: general review. J Steroid Biochem 35:157–172
Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N (1978) Estradiol reduces natural killer cells in mice. J Immunol 121:2193–2197
Solomon GB (1969) Host hormones and parasitic infection. Int Rev Trop Med 3:101–158
Spindler KD (1988) Parasites and hormones. In: Mehlhorn H (ed) Parasitology in focus. Facts and trends. Springer, Berlin Heidelberg New York, pp 465–476
Stimson WH (1987) Sex steroid receptors and immunity. In: Berczi I, Kovacs K (eds) Hormone and immunity. MTP Press, Lancaster, pp 43–53
Ubelaker JE (1986) Systematics of species referred to the genusAngiostrongylus. J Parasitol 72:237–244
Wilson JD (1990) Androgens. In: Gillman AG (ed) Goodman and Gilman's pharmacological basis of therapeutics. Pergamon, New York, pp 1413–1430
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Kamis, A.B., Ahmad, R.A. & Badrul-Munir, M.Z. Effects of estradiol on worm burden and peripheral leukocytes inParastrongylus malaysiensis-infected rats. Parasitol Res 80, 74–77 (1994). https://doi.org/10.1007/BF00932628
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DOI: https://doi.org/10.1007/BF00932628