Abstract
Larvae ofToxocara vitulorum hatched and migrated in the tissues of normal mice. Larvae survived in reasonable numbers, particularly in the liver and, to a lesser extent, in the lungs and kidneys, for at least 4–7 days and in muscles, albeit only in low numbers, for at least 3 weeks. Oral infection of mice on three or more occasions withT. vitulorum eggs induced protection against a challenge infection with eggs ofT. vitulorum. Prior parenteral immunization of mice with a variety ofT. vitulorum soluble antigens (extracts, excretions/secretions, or perienteric fluid and their fractions) from adult parasites and/or infective larvae induced statistically significant protection against infection. The most effective protective immunogens were three or more injections with perienteric fluid from adults (100% protection) and excretions/secretions from infective larvae ofT. vitulorum (>92% protection).
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Amerasinghe, P.H., Rajapakse, R.P.V.J., Lloyd, S. et al. Antigen-induced protection against infection withToxocara vitulorum larvae in mice. Parasitol Res 78, 643–647 (1992). https://doi.org/10.1007/BF00931514
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DOI: https://doi.org/10.1007/BF00931514