Abstract
Three strains (ACI, August and Wistar) of rats previously sensitized by oral infection with intact third-stage larvae ofAngiostrongylus cantonensis developed significant protective immunity to challenge infections 6 weeks later. The degree of the immunity was highest in the August strain of rats, followed by Wistar and ACI rats. Protective immunity appears to affect both third-stage larvae and fourth- and/or fifth-stage worms. ACI rats showed poor antibody responses, especially in the IgE fraction. When 24-day-old young adult worms were transferred from the brain of donor rats into the peritoneal cavity of sensitized rodents, peritoneal eosinophils predominantly adhered to the worm surfaces in vivo.
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Yoshimura, K., Ishida, K., Ishigooka, S. et al. Protective immunity againstAngiostrongylus cantonensis in rats following sensitizing infections. Parasitol Res 76, 26–31 (1989). https://doi.org/10.1007/BF00931067
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DOI: https://doi.org/10.1007/BF00931067