Abstract
Anin vitro kinetic study on inhibition of the monoamine oxidase-A (MAO-A) of the rat brain by two pyrethroids, namely permethrin (PM) and cypermethrin (CPM), has shown that PM and CPM competitively inhibit MAO-A by altering both the Michaelis-Menten constant (Km) and the maximum velocity (Vmax). Inhibitor constant values (Ki) indicated that CPM was a more effective inhibitor of MAO-A than PM. Both PM and CPM caused maximum inhibition of MAO-A at neutral pH. CPM significantly elevated the activation energy values of MAO-A as compared to those of PM.
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Abbreviations
- MAO:
-
Manoamine Oxidase
- PM:
-
Permethrin
- CPM:
-
Cypermethrin
- TTV:
-
Toxicity Test Value
- IC50 :
-
Inhibitor Concentration that causes 50 percent inhibition
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Rao, G.V., Rao, K.S.J. Inhibition of monoamine oxidase-A of rat brain by pyrethroids — anin vitro kinetic study. Mol Cell Biochem 124, 107–114 (1993). https://doi.org/10.1007/BF00929202
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DOI: https://doi.org/10.1007/BF00929202