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Poly(ADP-ribose): Historical perspective

  • Part I: Historical Perspective
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Abstract

The early historical background of the discovery of poly(ADP-ribose) and the following development of science on poly(ADP-ribose) are reviewed. Fundamental knowledge on the natures of poly(ADP-ribose), poly(ADP-ribose) polymerase and enzymes degrading poly(ADP-ribose) are summarized with brief description on the methodology for their purification and characterization. Future prospect of research on biological significance of poly(ADP-ribose) has also been discussed briefly.

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Authors and Affiliations

  1. National Cancer Center, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan

    Takashi Sugimura

  2. Department of Biochemistry, Institute of Medical Sciences, The University of Tsukuba, Tsukuba, Ibaraki 305, Japan

    Masanao Miwa

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  1. Takashi Sugimura
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  2. Masanao Miwa
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Sugimura, T., Miwa, M. Poly(ADP-ribose): Historical perspective. Mol Cell Biochem 138, 5–12 (1994). https://doi.org/10.1007/BF00928437

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