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History of the Discovery of Poly (ADP-ribose)

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PARP Inhibitors for Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D,volume 83))

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Abstract

This chapter describes the discovery of poly (ADP-ribose) and its associated enzymes, and the discovery of the function of poly (ADP-ribose) polymerase (PARP) in DNA repair and in the dynamic modification of chromatin. Poly (ADP-ribose) is a very unusual polymer in biology, it is ubiquitous in eukaryotes and functions crucially in the cellular response to DNA damage and probably also in chromatin conformation changes.

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Author information

Authors and Affiliations

  1. Emeritus, National Cancer Center, Tokyo, Japan

    Dr. Takashi Sugimura

  2. Japan Academy 7-32, Ueno Park, Taito-ku, 110-0007, Tokyo, Japan

    Dr. Takashi Sugimura

  3. Department of Haematological Medicine, The Rayne Institute, Kings College London Medical School, Denmark Hill Campus, SE5 9NU, London, England

    Sydney Shall

Authors
  1. Dr. Takashi Sugimura
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  2. Sydney Shall
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Corresponding author

Correspondence to Takashi Sugimura .

Editor information

Editors and Affiliations

  1. Northern Institute for Cancer Research and Newcastle University Institute for Ageing Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    Nicola J. Curtin

  2. CRUK-MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

    Ricky A. Sharma

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Sugimura, T., Shall, S. (2015). History of the Discovery of Poly (ADP-ribose). In: Curtin, N., Sharma, R. (eds) PARP Inhibitors for Cancer Therapy. Cancer Drug Discovery and Development, vol 83. Humana Press, Cham. https://doi.org/10.1007/978-3-319-14151-0_1

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  • DOI: https://doi.org/10.1007/978-3-319-14151-0_1

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-14150-3

  • Online ISBN: 978-3-319-14151-0

  • eBook Packages: MedicineMedicine (R0)

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