Abstract
When maintained under SPF (specific pathogen free) conditions, Wistar rats had low and variable counts of adultNippostrongylus brasiliensis. Worm counts were increased if rats were kept in solid rather than wire-bottom cages, if rats were maintained under non-SPF conditions, or if SPF rats were orally inoculated with gut contents from non-SPF rats. It is concluded that gut flora in SPF wistar rats directly or indirectly affects the numbers of larvae establishing as adult worms.
Similar content being viewed by others
References
Adams DB, Rothwell TLW (1977)Trichostrongylus colubriformis: host factors influencing the transfer of immunity in guinea pigs using mesenteric lymph node cells. Exp Parasitol 42:121–128
Chang J, Wescott RB (1972) Infectivity, fecundity, and survival ofNematospiroides dubius in gnotobiotic mice. Exp Parasitol 32:327–334
Doll JP, Franker CK (1963) Experimental histomoniasis in gnotobiotic turkeys. I. Infection and histopathology of the bacteria free host. J Parasitol 49:411–414
Houser BB, Burns WC (1968) Experimental infection of gnotobioticTenebrio molitor and white rats withHymenolepis diminuta (Cestoda: Cyclophyllidea). J Parasitol 54:69–73
Johnson J (1970) The development ofAscaridia galli in germ free chickens. J Parasitol 56:174
Newton WL, Weinstein PP, Jones MF (1959) A comparison of the development of some rat and mouse helminths in germ free and conventional guinea pigs. Ann NY Acad Sci 78:290–306
Przyjaŀkowski Z (1977) Establishment, growth and rate of expulsion of the cestodeHymenolepis nana Siebold, 1882 in germ free and conventional rats. Acta Parasitol Polon 25:63–68
Przyjaŀkowski Z (1978) Effect of intestinal flora on the course of infection and haematological changes in germ free and conventional mice exposed toTrichinella pseudospiralis (Garkavi, 1972). Bull Acad Polon Sci ser Sci Biol 26:331–336
Przyjaŀkowski Z, Cabaj W (1978) Some hematological and serological indicators in young conventional and germ free mice of different strains experimentally infected withTrichinella spiralis. Acta Parasitol Polon 26:96–103
Przyjaŀkowski ZW, Wescott RB (1969a)Trichinella spiralis: establishment in gnotobiotic mice affected byBacillus mesentericus, B. subtilis andPseudomonas aeruginosa. Exp Parasitol 25:8–12
Przyjaŀkowski ZW, Wescott RB (1969b) Effect of bacterial infection on the development ofNematospiroides dubius in gnotobiotic mice. Bull Acad Sci 17:57–60
Przyjaŀkowski Z, Wescott RB (1970) Influence of intestinal bacteria on the establishment ofNippostrongylus brasiliensis in gnotobiotic mice. Acta Parasitol Polon 17:265–269
Przyjaŀkowski Z, Cabaj W, Kontry E (1979a) Determination of the lethal dose ofTrichinella spiralis for germ free mice. Bull Acad Polon Sci Ser Sci Biol 27:61–68
Przyjaŀkowski Z, Cabaj W, Kontry E (1979b) IntestinalTrichinella spiralis infection in germ free and conventional mice treated with cyclophosphamide. Bull Acad Polon Sci Ser Sci Biol 27:109–115
Reid WM, Botero H (1967) Growth of the cestodeRaillietina cesticillus in bacteria-free chickens. Exp Parasitol 21:149–153
Wescott RB (1968) ExperimentalNematospiroides dubius infection in germ free and conventional mice. Exp Parasitol 22:245–249
Wescott RB, Todd AC (1964) A comparison of the development ofNippostrongylus brasiliensis in germ-free and conventional mice. J Parasitol 50:138–143
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Coles, G.C., Wells, P.D. The biology ofNippostrongylus brasiliensis in SPF rats. Z. Parasitenkd. 69, 517–521 (1983). https://doi.org/10.1007/BF00927708
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00927708