Abstract
Two groups of five two-year-old Hereford steers were infected with two virulent strains ofB. bovis. The plasma concentrations of creatine kinase (CK), lactate dehydrogenase (LDH), and creatinine rose early in infection and showed highly significant increases terminally. Extensive skeletal muscle degeneration was observed terminally as was degeneration of myocardium, although this was much less extensive. Terminal clinical signs included posterior muscle wasting, weakness, and recumbency. It was concluded that the extensive changes to muscle and to CK and LDH were caused by anoxia due primarily to shock and stasis of the circulation induced by the parasites.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Daniel RCW (1979) The effect of reducing plasma calcium levels on some plasma enzyme levels in cows and sheep. Br Vet J 135:30–39
Daniel RCW, Moodie EW (1978) The effect of induced hypocalcaemia on the cardiac output and blood pressure of dairy cattle. Res Vet Sci 24:380–382
Faulkner WR, King JW (1976) Renal function. In: Tietz NW (ed) Fundamentals of clinical chemistry, 2nd edition. Saunders, Philadelphia, p975
Goodger BV (1971) Preparation and preliminary assessment of purified antigens in the passive haemagglutination test for bovine babesiosis. Aust Vet J 47:251–256
Goodger BV, Wright IG (1977)Babesia bovis (argentina): observations of coagulation parameters, fibrinogen catabolism and fibrinolysis in intact and splenectomized cattle. Z Parasitenkd 54:9–27
Kachmar JF, Moss DW (1976) Enzymes. In: Tietz NW (ed) Fundamentals of clinical chemistry, 2nd edition. Saunders, Philadelphia, p565
Keller P, Martig J, Gerber H, Pauli B (1972) Beitrag zum Verhalten einiger Serumenzyme bei stoffwechselbedingten Geburtsfolgekrankheiten des Rindes. Schweiz Arch Tierheilkd 114:157–166
Mahoney DF, Wright IG (1976)Babesia argentina: immunization of cattle with a killed antigen against infection with a heterologous strain. Vet Parasitol 2:273–282
McConn R, Wasserman F, Haberland GL (1979) The effect of bradykinin infusion on hemodynamic and metabolic function in the control animals and hemorrhagic shock. Fed Proc 38:686
Shortt HE, Cooper W (1948) Staining of microscopical sections containing protozoal parasites by modification of McNamara's method. Trans R Soc Trop Med Hyg 41:427–428
Wright IG (1971) A study of the morphology and pathology of experimentally inducedBabesia argentina andBabesia bigemina infections in cattle, andBabesia canis infections in the dog. Ph. D. Thesis, University of Queensland
Wright IG (1974) The pathogenesis of acuteBabesia argentina infection. Proceedins 3rd International Congress of Parasitology 143–144
Wright IG (1975) The probable role ofBabesia argentina esterase in the in vitro activation of plasma prekallikrein. Vet Parasitol 1:91–96
Wright IG (1977) Kinin, kininogen and kiniase levels during acuteBabesia bovis (=B. argentina) infection of cattle. Br J Pharmacol 61:567–572
Wright IG (1980) Biochemical characteristics ofBabesia and physiochemical reactions in the host. In: Ristic M, Kreier JP (eds) Babesiosis. Academic Press, New York
Wright IG, Goodger BV (1979) AcuteBabesia bovis infections: renal involvement in the hypotensive syndrome. Z Parasitenkd 59:115–119
Wright IG, Goodger BV, McKenna RV, Mahoney DF (1979) AcuteBabesia bovis infection: a study of the vascular lesions in kidney and lung. Z Parasitenkd 60:19–27
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wright, I.G., McKenna, R.V. & Goodger, B.V. AcuteBabesia bovis infections: Plasma creatine kinase, lactate dehydrogenase and creatinine levels and associated muscle damage. Z. Parasitenkd. 64, 297–302 (1981). https://doi.org/10.1007/BF00927377
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00927377