Conclusions
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1.
The synthesis of 5-methylphenylamino- and 5-diphenylaminooxazole fromα-N-acylated amino acids and secondary amines of the type C6H5NHR in the presence of dehydrating agents has been carried out.
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2.
According to the13C NMR and PMR data, the introduction of 5-C6H5NR and (C6H5)2N groups into the oxazole ring results in a significant increase in the screening of the C4 and C2 carbon atoms and the unscreening of the C5 carbon atom.
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S. M. Birnbaum, L. Levintow, R. B. Kingsley, and J. P. Greenstein, J. Biol. Chem.,194, 455 (1952).
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Translated from IzvestiyaAkademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 894–898, April, 1978.
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Kondrat'eva, G.Y., Aitzhanova, M.A., Bogdanov, V.S. et al. Synthesis of 5-R2 N-oxazoles from α-N-acylated amino acids. Russ Chem Bull 27, 773–777 (1978). https://doi.org/10.1007/BF00925305
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DOI: https://doi.org/10.1007/BF00925305