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Correlation between CD11b/CD18 and increase of aggregability of granulocytes in coronary artery disease

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Abstract

Recent studies suggest that granulocytes (PMNs) play a role in the pathogenesis of acute and chronic myocardial ischemia and extension of myocardial injury. Rabbit-derived antiseram-dependent reduction of circulating PMNs in the dog or using monoclonal antibody anti-CD11b/CD 18 of PMNs resulted in smaller myocardial infarcts. Experience in humans shows the modification of PMN function in angina and during myocardial ischemia. In our studies, patients affected by coronary artery disease presented an increase in granulocyte aggregability in coronary sinus and showed a related higher expression of CD11b/CD18 in coronary sinus with respect to aorta leukocytes. The potential role of this modification of PMNs was analyzed.

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Authors and Affiliations

  1. Department of Internal Medicine and Therapeutics, Section of Medical Pathology, University of Pavia, Italy

    Antonino Mazzone, Davide Pasotti, Gianluca Fossati, Iolanda Hazzucchelli, Paola Cavigliano & Giovanni Ricevuti

  2. Division of Cardiology, IRCCS S. Matteo Hospital, P.le Golgi 2, 27100, Pavia, Italy

    Stefano De Servi

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  1. Antonino Mazzone
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  2. Davide Pasotti
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  3. Stefano De Servi
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  4. Gianluca Fossati
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  5. Iolanda Hazzucchelli
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  6. Paola Cavigliano
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  7. Giovanni Ricevuti
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Mazzone, A., Pasotti, D., De Servi, S. et al. Correlation between CD11b/CD18 and increase of aggregability of granulocytes in coronary artery disease. Inflammation 16, 315–323 (1992). https://doi.org/10.1007/BF00917624

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