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Coronary leukocyte activation in relation to progression of coronary artery disease

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Abstract

Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had twovessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.

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Authors and Affiliations

  1. Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, P.O. Box 10900, 3004 BA, The Netherlands

    Marijke A. de Vries, Arash Alipour, Andrew Westzaan, Selvetta van Santen, Noëlle van der Meulen & Manuel Castro Cabezas

  2. Department of Statistics and Education, Sint Franciscus Gasthuis, Rotterdam, P.O. Box 10900, 3004 BA, The Netherlands

    Erwin Birnie

  3. Department of Clinical Chemistry, Sint Franciscus Gasthuis, Rotterdam, P.O. Box 10900, 3004 BA, The Netherlands

    Ellen van der Zwan

  4. Department of Cardiology, Sint Franciscus Gasthuis, Rotterdam, P.O. Box 10900, 3004 BA, The Netherlands

    Anho H. Liem

Authors
  1. Marijke A. de Vries
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  2. Arash Alipour
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Correspondence to Marijke A. de Vries.

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de Vries, M.A., Alipour, A., Birnie, E. et al. Coronary leukocyte activation in relation to progression of coronary artery disease. Front. Med. 10, 85–90 (2016). https://doi.org/10.1007/s11684-016-0435-1

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  • DOI: https://doi.org/10.1007/s11684-016-0435-1

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