Abstract
Increases in pH from 7.4 to 7.8 decreased the ability of human neutrophils in serum to ingest and killEscherichia coli ATCC 29552 in vitro. In contrast, similar increases in pH did not decrease the bactericidal activity of neutrophils in serum againstStaphylococcus aureus 502A. Increases in pH did not alter opsonization ofE. coli by serum or the growth ofE. coli but rather appeared to alter neutrophil uptake of bacteria by a direct effect on the neutrophil.
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Berger, E.M., Murphy, K., Shibao, G.A. et al. Small increases in pH decrease uptake ofEscherichia coli by human neutrophils in vitro. Inflammation 12, 161–167 (1988). https://doi.org/10.1007/BF00916399
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DOI: https://doi.org/10.1007/BF00916399