Abstract
When human T cells were treated with neuraminidase fromVibrio cholerae, the capacity of T cells to form rosettes with autologous erythrocytes was markedly enhanced. The neuraminidase-treated T cells were separated with autologous erythrocytes into autorosetting and nonrosetting cell populations, and these two populations examined for their reactivity to mitogens and B cells and for their regulatory activities. Autorosetting T cells proliferated poorly in response to mitogens and autologous and allogeneic B cells; these cells were particularly enriched for cells capable of becoming concanavalin A-induced suppressor cells. Nonrosetting T cells capable of most actively proliferating in response to the mitogens and the B cells failed to exhibit such suppressor function after concanavalin A activation. Coculture experiments between autorosetting and nonrosetting cells further demonstrated that the nonrosetting T cells were able to potentiate the proliferation of the autorosetting T cells with concomitant expression of the suppressor properties.
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Sakane, T., Honda, M., Taniguchi, Y. et al. Characterization of human peripheral blood T lymphocytes bearing receptors for autologous erythrocytes and T lymphocytes lacking these receptors. J Clin Immunol 2, 20–29 (1982). https://doi.org/10.1007/BF00915974
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DOI: https://doi.org/10.1007/BF00915974