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Inhibition of acetylcholinesterase by O,O-diethyl S-[β-(arylmethylamino)ethyl]thiophosphates and their methyl sulfates

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The rate constants for the inhibition of acetycholinesterase by O,O-diethyl S-[β-(arylmethylamino)ethyl] thiophosphates and their methyl sulfates were determined.

  2. 2.

    Changes in the inhibiting capacity in the series of O,O-diethyl S-[β-(arylmethylamino)ethyl] thiophosphates toward acetylcholinesterase are associated mainly with the polar effects of the substituents in the benzene ring, whereas the anticholinesterase activity of the corresponding methyl sulfates is little dependent on the substituent.

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Literature cited

  1. A. P. Brestkin, I. L. Brik, R. I. Volkova, N.N. Godovikov, M. I. Kabachnik, and N. E. Teplov, DAN SSSR,163, 365 (1965).

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, USSR

    A. P. Brestkin, I. L. Brik, L. I. Ginetsinskaya, N. N. Godovikov, M. I. Kabachnik & N. E. Teplov

Authors
  1. A. P. Brestkin
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  2. I. L. Brik
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  3. L. I. Ginetsinskaya
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  4. N. N. Godovikov
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  5. M. I. Kabachnik
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  6. N. E. Teplov
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2070–2073, September, 1968.

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Brestkin, A.P., Brik, I.L., Ginetsinskaya, L.I. et al. Inhibition of acetylcholinesterase by O,O-diethyl S-[β-(arylmethylamino)ethyl]thiophosphates and their methyl sulfates. Russ Chem Bull 17, 1966–1968 (1968). https://doi.org/10.1007/BF00904993

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  • DOI: https://doi.org/10.1007/BF00904993

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