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Synthesen und reaktionen von pyridazinderivaten, 1. Mitt.: a) Eine neue synthese der pyridazin-4-carbonsäure, b) Darstellung und reaktionen von 3-oxo-3-(4′-pyridazinyl)-propionsäureäthylester

Syntheses and reactions of pyridazine derivatives. 1st comm.: a) A new synthesis of pyridazine-4-carboxylic acid, b) synthesis and reactions of ethyl-3-oxo-3-(4′-pyridazinyl)-propionate

  • Organische Chemie und Biochemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

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Abstract

Pyridazine-4-carboxylic acid is prepared in high yield by catalytic hydrogenation of 3.6-dichloropyridazine-4-carboxylic acid.Claisen condensation of its ethyl ester with ethyl acetate yields ethyl 3-oxo-3-(4′-pyridazinyl)-propionate (6), the condensation reactions of which with urea, thiourea, phenylhydrazine and hydroxylamine are described. 4-Acetylpyridazine is prepared from6.

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Authors and Affiliations

  1. Pharmazeutisch-Chemischen Institut der Universität Wien, Österreich

    G. Heinisch

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  1. G. Heinisch
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Herrn Prof. Dr.K. Jentzsch mit besten Wünschen zum 60. Geburtstag gewidmet.

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Heinisch, G. Synthesen und reaktionen von pyridazinderivaten, 1. Mitt.: a) Eine neue synthese der pyridazin-4-carbonsäure, b) Darstellung und reaktionen von 3-oxo-3-(4′-pyridazinyl)-propionsäureäthylester. Monatshefte für Chemie 104, 953–962 (1973). https://doi.org/10.1007/BF00903909

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  • DOI: https://doi.org/10.1007/BF00903909

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