Skip to main content
SpringerLink
Log in

The dose effect ofma-l + andry + on xanthine dehydrogenase activity inDrosophila melanogaster

  • Published:
Zeitschrift für Vererbungslehre Aims and scope Submit manuscript

Summary

Two loci,ma-l + andry +, necessary for xanthine dehydrogenase activity inDrosophila melanogaster have been studied for dosage effects utilizing deficiencies and duplications induced for this purpose. Comparisons of one, two and three doses ofma-l + in the female or one and two doses in the male indicate that there is no increase in specific enzyme activity with dose. On the other hand, comparisons of one, two and three doses ofry + in the male and female reveal an increase in enzyme activity that is roughly proportional to dose. Since dosage ofry + is limiting, whereas that ofma-l + is not, the final concentration of xanthine dehydrogenase is shown to depend on the number of doses ofry +.

The implications of these findings with respect to the hypothesis of dosage compensation and to the mechanism of control of enzyme and protein concentration are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  • Bennhold, H.: Kongenitale defektdysproteinamien. Verh. dtsch. Ges. inn. Med.62, 657–667 (1956).

    Google Scholar 

  • Bretthauer, R. K., R. G. Hansen, G. Donnell andW. R. Bergen: A procedure for detecting carriers of galactosemia. Proc. nat. Acad. Sci. (Wash.)45, 328–331 (1959).

    Google Scholar 

  • Bridges, C. B., andK. S. Brehme.: The mutants ofDrosophila melanogaster Carnegie Inst. Wash. Publ.552, 257 pages (1944).

  • Brosseau, G. E., B. Nicoletti, E. H. Grell, andD. L. Lindsley: Production of altered Y chromosomes bearing specific sections of the X chromosome in Drosophila. Genetics46, 339–346 (1961).

    Google Scholar 

  • Egelhaaf, A., andE. Caspari: Über die Wirkungsweise und genetische Kontrolle des Tryptophanoxydasesystems beiEphestia kühniella. Z. Vererb.-Lehre91, 373–379 (1960).

    Google Scholar 

  • Forrest, H. S., E. Glassman andH. K. Mitchell: Conversion of 2-amino-4-hydroxypteridine to isoxanthopterin inDrosophila melanogaster. Science124, 725–726 (1956).

    Google Scholar 

  • Glassman, E.: Complementation at the maroon-like eye color locus ofDrosophila melanogaster. Science131, 1810 (1960).

    Google Scholar 

  • —, andH. K. Mitchell: Mutants ofDrosophila melanogaster deficient in xanthine dehydrogenase. Genetics44, 153–162 (1959).

    Google Scholar 

  • Graham, J. B.: Biochemical genetics of blood coagulation. Amer. J. hum. Genet.8, 63–79 (1956).

    Google Scholar 

  • Hadorn, E., u.I. Schwink: Fehlen von Isoxanthopterin und Nicht-Autonomie in der Bildung der roten Augenpigmente bei einer Mutante (rosy 2) vonDrosophila melanogaster. Z. indukt. Abstamm.-u. Vererb.-Lehre87, 528–553 (1956).

    Google Scholar 

  • Hsia, D. Y. Y., K. W. Driscoll, W. Troll andW. E. Knox: Detection by phenylalanine tolerence tests of heterozygous carriers of phenylketonuria. Nature (Lond.)178, 1239 (1956).

    Google Scholar 

  • Hubby, J. L., andH. S. Forrest: Studies on the mutant maroon-like inDrosophila melanogaster. Genetics45, 211–224 (1960).

    Google Scholar 

  • Lowry, O. H., N. J. Rosebrough, A. L. Farr andR. J. Randall: Protein measurement with the Folin phenol reagent. J. biol. Chem.193, 265–275 (1951).

    Google Scholar 

  • Mitchell, H. K., E. Glassman, E. Hadorn: Hypoxanthine in rosy and maroon-like mutants ofDrosophila melanogaster. Science129, 268–269 (1959).

    Google Scholar 

  • Muller, H. J.: Further studies on the nature and causes of gene mutations. Proc. 6th Int. Congr. Genet.1, 213–255 (1932).

    Google Scholar 

  • —: Evidence of the precision of genetic adaptation. Harvey Lecture Series XLIII, vol. 1, pp. 165–229, Springfield, Ill: Charles C. Thomas 1950.

    Google Scholar 

  • Sawin, R. B., andD. Glick: Atropinesterase, a genetically determined enzyme in the rabbit. Proc. nat. Acad. Sci. (Wash.)29, 55–59 (1943).

    Google Scholar 

  • Takahara, S., H. Sato, M. Doi andS. Mihara: Acatalasemia. III. On the heredity of acatalasemia. Proc. Japan. Acad.28, 585–588 (1952).

    Google Scholar 

  • Ursprung, H.: Weltere Untersuchungen zu Komplementarität und Nicht-Autonomie der Augenfarb-Mutantenma-l undma-l bz vonDrosophila melanogaster. Z. Vererb.-Lehre92, 119–125 (1961).

    Google Scholar 

  • Woolf, L. I.: Gene expression in heterozygotes. Nature (Lond.)194, 609–610 (1962).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    E. H. Grell

Authors
  1. E. H. Grell
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Operated by Union Carbide Corporation for the U.S. Atomic Energy Commission.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grell, E.H. The dose effect ofma-l + andry + on xanthine dehydrogenase activity inDrosophila melanogaster . Zeitschrift für Vererbungslehre 93, 371–377 (1962). https://doi.org/10.1007/BF00888795

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00888795

Keywords

Search

Navigation