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A brief history of dosage compensation

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Abstract

In 1914, H. J. Muller postulated the origin of the Y chromosome as having resulted from restricted recombination between homologous sex chromosomes in the male and the accumulation of deleterious mutations. This evolutionary process leads to dosage compensation. This article lays out a brief history of dosage compensation in genetics.

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  1. Medicine (Medical Genetics), Genome Sciences and Pathology, University of Washington, 850 Republican St., Seattle, WA, 98109, USA

    STANLEY M. GARTLER

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  1. STANLEY M. GARTLER
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Correspondence to STANLEY M. GARTLER.

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[Gartler S. M. 2014 A brief history of dosage compensation. J. Genet. 93, xx–xx]

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GARTLER, S.M. A brief history of dosage compensation. J Genet 93, 591–595 (2014). https://doi.org/10.1007/s12041-014-0360-5

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  • DOI: https://doi.org/10.1007/s12041-014-0360-5

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