Method of isolating the carotid sinus and further proof of the reflex production of antibodies

Summary

The method we suggest allows the complete isolation of the carotid sinus without injury to the sinus nerve. The administration of radioactive vaccine containing 100–400 μC per 1 ml of radioactive phosphorus into the sinus isoiated by the method described above and the subsequent determination of the radioactivity of the blood testified to the complete absence of resorption from the isolated sinus. Preliminary section of the sinus nerve eliminated the production of specific agglutinins during the administration of typhoid fever vaccine into the isolated carotid sinus. Preliminary inclusion of the sinus nerve in the ligated bundle sharply deereased the production of antibodies. The data obtained testify to the presence of a reflex mechanism in the production of antibodies.