Advertisement

Pediatric Nephrology

, Volume 9, Issue 4, pp 447–450 | Cite as

Ureteral obstruction in the neonatal rat: Renal nerves modulate hemodynamic effects

  • Robert L. Chevalier
  • Barbara A. Thornhill
Original Article

Abstract

In the neonate, chronic unilateral ureteral obstruction (UUO) reduces renal blood flow (RBF) of the ipsilateral kidney and increases RBF of the opposite kidney. To determine whether renal nerves mediate or modulate these responses complete left UUO in the neonatal rat was used as a model of severe obstructive uropathy, and was compared with sham-operated controls. At 24–28 days of age, animals underwent left or right mechanical renal denervation or left sham renal denervation. One week after denervation, animals were anesthetized and blood pressure and heart reate were measured. Cardiac output and RBF were determined by the radioactive microsphere technique. UUO increased blood pressure and heart rate, and decreased RBF in the obstructed kidney, regardless of denervation. While left UUO increased RBF to the intact opposite kidney in rats with left renal denervation, this was attenuated by right renal denervation. Thus, in the neonatal rat, UUO modulates systemic renal hemodynamics, possibly through activation of the renin-angiotensin system. While renal nerves do not mediate the vasoconstriction of the obstructed kidney, renal nerves modulate vascular tone of the kidney contralateral to UUO.

Key words

Ureteral obstruction Neonate Renal nerves Rat 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Najarian JS, Almond PS, Gillingham KJ, Mauer SM, Chavers BM, Nevins TE, Kashtan CE, Matas AJ (1993) Renal transplantation in the first five years of life. Kidney Int 44:S40-S44Google Scholar
  2. 2.
    Chevalier RL (1990) Renal response to ureteral obstruction in early development. Nephron 56:113–117Google Scholar
  3. 3.
    Chevalier RL (1990) Counterbalance in functional adaptation to ureteral obstruction during development. Pediatr Nephrol 4:442–444Google Scholar
  4. 4.
    Taki M, Goldsmith DI, Spitzer A (1983) Impact of age on effects of ureteral obstruction on renal function. Kidney Int 24:602–609Google Scholar
  5. 5.
    Larsson L, Aperia A, Wilton P (1980) Effect of normal development on compensatory renal growth. Kidney Int 18:29–35Google Scholar
  6. 6.
    El Dahr SS, Gomez RA, Gray MS, Peach MJ, Carey RM, Chevalier RL (1991) Renal nerves modulate renin gene expression in the developing rat kidney with ureteral obstruction. J Clin Invest 87:800–810Google Scholar
  7. 7.
    Norwood VF, Carey RM, Geary KM, Jose PA, Gomez RA, Chevalier RL (1994) Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells. Kidney Int 45:1333–1339Google Scholar
  8. 8.
    El-Dahr SS Gomez RA, Gray MS, Peach MJ, Carey RM, Chevalier RL (1990) In situ localization of renin and its mRNA in neonatal ureteral obstruction. Am J Physiol 258:F854-F862Google Scholar
  9. 9.
    Chevalier RL, Kaiser DL (1984) Chronic partial ureteral obstruction in the neonatal guinea pig. I. Influence of uninephrectomy on growth and hemodynamics. Pediatr Res 18:1266–1271Google Scholar
  10. 10.
    DiBona GF (1985) Neural regulation of renal tubular sodium reabsorption and renin secretion. Federation Proc 44:2816–2822Google Scholar
  11. 11.
    Nakamura A, Johns EJ (1994) Effect of renal nerves on expression of renin and angiotensinogen genes in rat kidneys. Am J Physiol Endocrinol Metab 266:E230-E241Google Scholar
  12. 12.
    Chevalier RL, Thornhill BA (1995) Ureteral obstruction in the neonatal rat. II. Interaction of sympathetic nerves and angiotensin. Pediatr Nephrol (in press)Google Scholar
  13. 13.
    Holmer S, Rinne B, Eckardt KU, Le Hir M, Schricker K, Kaissling B, Riegger G, Kurtz A (1994) Rore of renal nerves for the oxy pression of renin in adult rat kidney. Am J Physiol 266:F738-F745Google Scholar
  14. 14.
    Wilson DR, Honrath U, Sole M (1979) Effect of acute and chronic renal denervation on renal function after release of unilateral ureteral obstruction in the rat. Can J Physiol Pharmacol 57:731–737Google Scholar
  15. 15.
    Moss NG (1982) Renal function and renal afferent and efferent nerve activity. Am J Physiol 243:F425-F433Google Scholar
  16. 16.
    Torikai S (1988) A renorenal suppression in response to atrial natriuretic peptide in the unilateral ischaemic rat. Clin Sci 74:519–525Google Scholar
  17. 17.
    Kopp UC (1985) Renorenal reflexes: neral and functional responses. Fed Proc 44:2834–2839Google Scholar
  18. 18.
    Szenasi G, Kottra G, Bencsath P, Takacs L (1988) Renal nerves in exaggerated water and sodium excretion by hypertrophied kidney of anesthetized rats. Am J Physiol 254:F32-F37Google Scholar

Copyright information

© IPNA 1995

Authors and Affiliations

  • Robert L. Chevalier
    • 1
  • Barbara A. Thornhill
    • 1
  1. 1.Department of PediatricsUniversity of Virginia, School of MedicineCharlottesvilleUSA

Personalised recommendations