Conclusions
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1.
The rate constants were determined for the reaction of O-n-alkyl S-(β-ethylmercaptoethyl) methylthiophosphonates and their methyl sulfomethylates with acetylcholinesterase.
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2.
The ability of the studied compounds to react with acetylcholinesterase depends to a considerable degree on their ability to be sorbed on the active surface of the enzyme, both via hydrophobic interactions and via ionic sorption.
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3.
The previously expressed theory that one hydrophobic segment, spatially corresponding to the n-butyl group, is present in the region of the esterase center of acetylcholinesterase was corroborated.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1169–1172, May, 1972.
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Abduvakhabov, A.A., Godovikov, N.N., Kabachnik, M.I. et al. Reaction of O-n-alkyl S-(β-ethylmercaptoethyl) methylthiophosphonates and their methyl sulfomethylates with acetylcholinesterase. Russ Chem Bull 21, 1117–1120 (1972). https://doi.org/10.1007/BF00853782
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DOI: https://doi.org/10.1007/BF00853782