Abstract
To evaluate the clinical usefulness of IMP SPECT in the diagnosis of epilepsy, 6 normals and 52 patients in the interictal phase were studied. Thirty min after an intravenous injection of 111 MBq IMP, SPECT was performed using a rotating gamma camera. Of 21 patients with simple partial seizures, a localized decrease of uptake was shown in 16, and an increase in 3. Topologically, these findings corresponded well to the ictal symptoms. Nine of 13 patients with localized epileptic EEG had a good correspondence between the findings on EEG and IMP SPELT. In 20 of 23 with complex partial seizures, the coronal images showed laterality of uptake in the temporal lobes, whereas the CT was normal in 14. However, these findings on IMP SPECT agreed with the EEG in the temporal leads in only 5 cases. Of 8 patients with primary generalized seizures, a diffuse cerebral decrease was shown in 3 of 4 patients with convulsive seizures (grand mal), and a normal uptake in 3 of 4 patients with non-convulsive seizures (petit mal). However, 2 patients showed a localized decrease, therefore, we determined that they suffered from partial seizures evolving to secondarily generalization. From these data, we concluded that IMP SPELT could be a useful method in the diagnosis of epilepsy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bajorek JG, Lee RJ, Lomax P (1986) Neuropeptides: anticonvulsant and convulsant mechanisms in epileptic model systems and in humans. Adv Neurol 44:489–500
Bloom RJ, Vinuela F, Fox AJ, Blume WT, Girvin J, Kaufman JCE (1984) Computed tomography in temporal lobe epilepsy. J Comput Assist Tomogr 8:401–405
Brazier MAB (1972) Spread of seizure discharges in epilepsy: anatomical and electrophysiological considerations. Exp Neurol 36:263–272
Commission on Classification and Terminology of the International League Against Epilepsy (1981) Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 22:489–501
Defer G, Moretti JL, Cesaro P, Sergent A, Raynaud C, Degos JD (1987) Early and delayed SPECT using N-isopropyl-p-iodoamphetamine Iodine 123 in cerebral ischemia; a prognostic index for clinical recovery. Arch Neurol 44:715–718
Engel J Jr, Kuhl DE, Phelps ME, Mazziotta JC (1982a) Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes. Ann Neurol 12:510–517
Engel J Jr, Kuhl DE, Phleps ME (1982b) Patterns of human local cerebral glucose metabolism during epileptic seizures. Science 218:64–66
Freak H (1983) Pro- and anticonvulsant actions of morphine and the endogenous opioids: involvement and interactions of multiple opiate and non-opiate systems. Brain Res 6:197–210
Gastaut H, Gastaut JL (1976) Computerized transverse axial tomography in epilepsy. Epilepsia 17:325–336
Gloor P (1968) Generalized cortico-reticular epilepsies some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge. Epilepsia 9:249–263
Hill TC, Holman BL, Lovett R, O'Leary DH, Front D, Magistretti P, Zimmerman RE, Moore S, Clouse ME, Wu JL, Lin TH, Baldin RM (1982) Initial experience with SPECT (single-photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication. J Nucl Med 23:191–195
Hougaard K, Oikawa T, Sveinsdottir E, Skinhøj E, Ingvar DH, Lassen NA (1976) Regional cerebral blood flow in focal cortical epilepsy. Arch Neurol 33:527–535
Ingvar DH (1973) Regional cerebral blood flow in focal cortical epilepsy. Stroke 4:359–360
Komai S, Onuma J, Toyoda J, Miyazaki C, Sugai Y (1984) Study of epilepsy by positron CT. Annual report of research entitled “Cause and treatment of refractory epilepsies”. Ministry of Health and Welfare, Japan, pp 119–125
Kuhl DE, Engel J Jr, Phelps ME, Selin C (1980) Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of18FDG and13NH3. Ann Neurol 8:348–360
Kuhl DE, Barrio JR, Huang S-C, Selin C, Ackermann RF, Lear JL, Wu JL, Lin TH, Phelps ME (1982) Quantifying local cerebral blood flow by N-isopropyl-p-[123I] iodoamphetamine (IMP) tomography. J Nucl Med 23:196–203
Lavy S, Melamed E, Portnoy Z, Carmen A (1976) Interictal regional cerebral blood flow in patients with partial seizures. Neurology 26:418–422
Lieb JP, Walsh GO, Babb TL, Walter RD, Crandall PH (1976) A comparison of EEG seizure patterns recorded with surface and depth electrodes in patients with temporal lobe epilepsy. Epilepsia 17:137–160
Magistretti PL, Uren RF, Parker JA, Royal HD, Front D, Kolodny GM (1983) Monitoring of regional cerebral blood flow by single photon emission tomography of I123-N-isopropyl-iodoamphetamine in epileptics. Ann Radiol (Paris) 26:68–71
Penfeld W, Jasper H (1954) Epilepsy and the functional anatomy of the human brain. Little Brown, Boston
Sakai F, Meyer JS, Naritomi H, Hsu M-C (1978) Regional cerebral blood flow and EEG in patients with epilepsy. Arch Neurol 35:648–657
Sanabria E, Chauvel P, Askienazy S, Vignal JP, Trottier S, Chodkiewicz JP, Bancaud J (1983) Single photon emission computed tomography (SPECT) using123I-isopropyl-iodoamphetamine (IAMP) in partial epilepsy. In: Baldy-Moulinier M, Ingvar DH, Meldrum BS (eds) Current problem in epilepsy, Vol 1. Libbey Eurotext, London Paris, pp 82–87
Tada K, Iinuma K, Taniuti K, Yanagisawa T, Fueki N, Matsuzawa T, Ito M, Hatazawa J (1984) Local cerebral glucose metabolism by positron emission tomography in a case with intractable tonic seizures. Annual report of research entitled “Cause and treatment of refractory epilepsies.” Ministry of Health and Welfare, Japan, pp 127–131
Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H (1980) N-isopropyl-(1231) p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain. J Nucl Med 21:947–952
Author information
Authors and Affiliations
Additional information
This paper was presented at the 4th Asia Oceania Congress of Nuclear Medicine in Taipei City in 1988
Rights and permissions
About this article
Cite this article
Kawamura, M., Murase, K., Kimura, H. et al. Single photon emission computed tomography (SPELT) using N-isopropyl-p-(123I)iodoamphetamine (IMP) in the evaluation of patients with epileptic seizures. Eur J Nucl Med 16, 285–292 (1990). https://doi.org/10.1007/BF00842781
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00842781