Abstract
The purpose of this study was to examine the longitudinal effect of gradual coronary occlusion on regional myocardial metabolism of 15-p-123I-iodophenyl pentadecanoic acid ([123I]IPPA). Adult dogs were imaged using [123I]IPPA and planar gamma imaging. A thoracotomy was performed and an ameroid constrictor of appropriate size permanently positioned on the left anterior descending coronary artery. The dogs were imaged after injection of 3–5 mCi [123I]IPPA at various times over a 2-week period. With imaging on days 7 and 14, the dogs were paced at a rate of 185. Time-activity curves were generated and t1/2 values calculated using monoexponential curve fitting. Results indicate a significant increase in t1/2 between control and 14 days after surgery in the apical wall (29±7 to 53±18 min;P<0.05). Although there was also an increased t1/2 in the lateral wall, this was not significant (27±8 to 78±99 min;P > 0.05). There was no significant change in t/12 in the septal wall (27±9 to 33±8 min;P>0.05). We conclude that [123I]IPPA is a useful indicator of
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This work was supported by the British Columbia Heart Foundation
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Hudon, M.P.J., Lyster, D.M., Jamieson, W.R.E. et al. The metabolism of 15-p-[123I]-iodophenylpentadecanoic acid in a surgically induced canine model of regional ischemia. Eur J Nucl Med 16, 199–204 (1990). https://doi.org/10.1007/BF00842769
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DOI: https://doi.org/10.1007/BF00842769