Abstract
The nature of suppressor cells contained in a suspension of splenic lymphocytes immunized with allogeneic spleen cells and inhibiting activation of DNA synthesis in mixed lymphocyte cultures was studied. The suppressor cells were resistant to mitomycin C and carrageenin, were not inactivated by treatment with rabbit anti-B- and anti-Ig or mouse antibodies (anti-Mls serum) against B-lymphocytes, in the presence of complement, but were eliminated by rabbit antilymphocytic globulin and also by antibodies against T-lymphocytes (rabbit ATG and anti-θ-serum). The T-suppressors studied were concentrated in the large lymphocyte fraction in a ficoll gradient. Blocking of activation of DNA synthesis by these cells has a well-marked nonspecific component.
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Karaulov, A.V., Abronina, I.F. & Brondz, B.D. Induction of T-suppressors during immunization with allogeneic spleen cells in the mouse H-2 system. Bull Exp Biol Med 88, 1147–1150 (1979). https://doi.org/10.1007/BF00838190
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DOI: https://doi.org/10.1007/BF00838190