Abstract
One of the main problems regarding the follow-up of patients with brain tumours treated with radiotherapy is the distinction between radiation necrosis and tumour relapse. In many cases computed tomography (CT) scan is unable to distinguish between the two. We assessed the usefulness of brain single-photon emission tomography (SPET) with technetium-99m-sestamibi in cases where CT scan was not conclusive. The absence of tracer uptake in normal brain, the sharp uptake in neoplastic tissue, and the favourable physical properties of technetium make the scintigraphic method particularly accurate. We therefore propose the association of CT scan with99mTc-sestamibi brain SPET in the follow-up of patients in whom a distinction between radiation necrosis and active disease is needed for an adequate therapeutic decision.
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References
Valk PE, Dillon WP. Diagnostic imaging of central nervous system radiation injury. In: Gutin PH, Leibel SA, Sheline GE, eds.Radiation injury to the central nervous system. New York: Raven Press; 1991: 211–237.
Muller ST, Guth-Tougelides B, Creutzig H. Imaging of malignant tumours with Tc-99m-MIBI SPECT.J Nucl Med 1987; 30: 845.
Piwnica-Worms D, Holman BL. Noncardiac applications of hexakis(alkylisonitrile) technetium-99m complexes.J Nucl Med 1990; 31: 1166–1167.
O'Tuama LA, Treves ST, Larar JN. Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumours: a within-subject comparison.J Nucl Med 1993; 34: 1045–1051.
Macapinlac H, Scott A, Caluser C, et al. Comparison of Tl201 and Tc-99m-2-methoxy isobutyl isonitrile (MIBI) with MRI in the evaluation of recurrent brain tumors.J Nucl Med 1992: 33: 867.
Mountz JM, Rosenfeld SS, Li Y. Utility of Tl-201 and Tc-99m-sestamibi SPECT for early determination of malignant tumor chemotherapy efficacy.J Nucl Med 1993; 34: 206P.
Kostakoglu L, Uzal D, Gülaldi N, Uysal U, Caner B, Aras T, Ugur Ö, Bekdik CF. Detection of residual malignant brain tumors using Tc-99m-tetrofosmin: comparison with Tl-201 and Tc-99m-sestamibi.Eur J Nucl Med 1995; 22: 867.
Gerundini P, Maffioli L. Cationic complexes of technetium for myocardial imaging.J Nucl Med 1989; 30: 1415–1419.
Savi A, Gerundini P, Zoli P, Maffioli L, Compierchio A, Colombo F, Matarrese M, Deutsch E. Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans.Eur J Nucl Med 1989; 15: 597–600.
Chin M, Kronauge JF, Piwnica-Worms D, et al. Effect of mitochondrial and plasma-membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium (1) in cultured mouse fibroblasts.J Nucl Med 1990; 31: 1646–1653.
Piwnica-Worms D, Kronauge JF, Chin ML. Uptake and retention of hexakis (2-methoxyisobutylisonitrile) technetium (1) in cultured chick myocardial cells: mitochondrial and plasma membrane potential-dependence. Circulation 1990; 82: 1826–1838.
Delmon-Moingeon LI, Piwnica-Worms D, Van den Abbeele AD, Holman BL, Davison A, Jones AG. Uptake of the cation of hexakis (2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cell lines in vitro.Cancer Res 1990; 50: 2198–2202.
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Maffioli, L., Gasparini, M., Chiti, A. et al. Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours. Eur J Nucl Med 23, 308–311 (1996). https://doi.org/10.1007/BF00837629
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DOI: https://doi.org/10.1007/BF00837629