Abstract
During incubation of spleen cells from (CBA x C57BL)F1 mice immunized with rat erythrocytesin vitro with syngenetic erythrocytes a suppressor factor inhibiting the immune response to sheep's erythrocytes is secreted. On intravenous immunization the factor is secreted by thymus and spleen cells, but not by bone marrow or lymph node cells. The factor is probably antigen-nonspecific and is secreted by nonspecific T suppressors on contact with syngeneic erythrocytes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. P. Leskov, A. N. Cheredeev, and V. V. Solov'ev, Byull. Éksp. Biol. Med., No. 3, 308 (1977).
J. C. Gluchun and P. Montambault, Clin. Exp. Immunol.,22, 302 (1975).
N. K. Jerne, A. A. Nordin, and C. Henry, in: Cell-Bound Antibodies, (ed. by A. Amos and H. Koprowski), Philadelphia (1963), p. 109.
M. Lambermont, J. Wybran, and A. Govaerts, J. Immunol. Methods,15, 157 (1977).
Rights and permissions
About this article
Cite this article
Leskov, V.P., Cheredeev, A.N. & Solov'ev, V.V. Secretion of a suppressor factor by mouse lymphocytes on contact with syngeneic erythrocytes. Bull Exp Biol Med 88, 1315–1317 (1979). https://doi.org/10.1007/BF00835583
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00835583