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Effect of neuromediators on the antinociceptive effect of mesencephalic stimulation in rats

  • Pharmacology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The action of L-tryptophan (25 mg/kg, intraperitoneally) and microinjection of serotonin (20 μg), dopamine (10 μg), and neostigmine (5 μg) into the circum aqueductal gray matter on the antinociceptive effect of stimulation of the same points of the mesencephalon was studied in rats with implanted cannula-electrodes. L-tryptophan, serotonin, and neostigmine (after preliminary injection of methylatropine) potentiated the effect of subthreshold antinociceptive stimulation, tested with respect to changes in thresholds of appearance of individual components of the complex nociceptive response to electrical stimulation of the rat's tail. Dopamine did not possess this action. The potentiating effect of serotonin is not abolished by naloxone.

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Authors
  1. A. S. Morozova
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  2. A. V. Val'dman
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Additional information

Department of Pharmacology, First Leningrad Medical Institute. Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 11, pp. 551–553, November, 1979.

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Morozova, A.S., Val'dman, A.V. Effect of neuromediators on the antinociceptive effect of mesencephalic stimulation in rats. Bull Exp Biol Med 88, 1282–1284 (1979). https://doi.org/10.1007/BF00835572

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  • DOI: https://doi.org/10.1007/BF00835572

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