Skip to main content
SpringerLink
Log in

Abolition of the presynaptic action of carbachol by tubocurarine

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The presynaptic action of carbachol (C) was studied in experiments on a neuromuscular preparation of the sartorius muscle ofRana ridibunda. C was shown to significantly reduce the quantum composition of the endplate potentials (mEPP) as a result of the direct action of C on motor nerve endings. D-Tubocurarine caused a marked decrease in the sensitivity of motor nerve endings to C. Relations between C and tubocurarine as regards their action on the quantum composition of mEPP were of the competitive antagonism type. Atropine, in low concentrations, had no effect on the presynaptic action of C. The results of these experiments indicate that the decrease in mEPP under the influence of C is mediated through specific nicotinic cholinergic structures of motor nerve endings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. I. N. Volkova, E. E. Nikol'skii, and G. I. Poletaev, Fiziol. Zh. SSSR,61, 1433 (1975).

    Google Scholar 

  2. I. N. Volkova, E. E. Nikol'skii, G. I. Poletaev, et al., in: Abstracts of Scientific Proceedings of the 12th Congress of the All-Union Physiological Society [in Russian], Tbilisi (1975), p. 6.

  3. I. V. Komissarov, Elements of the Theory of Receptors in Molecular Pharmacology [in Russian], Moscow (1969).

  4. M. Ya. Mikhel'son and É. V. Zeimal', Acetylcholine [in Russian], Leningrad (1970).

  5. A. Auerbach and W. Betz, J. Physiol. (London),213, 691 (1971).

    Google Scholar 

  6. J. A. B. Barsted and L. Lillehei, Arch. Int. Pharmacodyn.,175, 379 (1968).

    Google Scholar 

  7. R. Beranek and F. Vyskocil, J. Physiol. (London),195, 493 (1968).

    Google Scholar 

  8. J. del Castillo and B. Katz, J. Physiol. (London),124, 560 (1954).

    Google Scholar 

  9. S. Ciani and C. Edwards, J. Pharmacol. Exp. Ther.,142, 21 (1963).

    Google Scholar 

  10. C. Edwards and K. Ikeda, J. Pharmacol. Exp. Ther.,138, 332 (1962).

    Google Scholar 

  11. D. Elmqvist and J. Quastel, J. Physiol. (London),177, 463 (1965).

    Google Scholar 

  12. J. I. Hubbard, R. F. Schmidt, and T. Yokota, J. Physiol. (London),181, 810 (1965).

    Google Scholar 

  13. J. I. Hubbard, D. F. Wilson, and M. Miyamoto, Nature,223, 531 (1969).

    Google Scholar 

  14. B. Katz, Proc. Roy. Soc. London B,155, 455 (1962).

    Google Scholar 

  15. W. F. Riker, Arch. Neurol. (Chicago),3, 488 (1960).

    Google Scholar 

Download references

Authors
  1. E. E. Nikol'skii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. Giniatullin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nikol'skii, E.E., Giniatullin, R.A. Abolition of the presynaptic action of carbachol by tubocurarine. Bull Exp Biol Med 87, 154–157 (1979). https://doi.org/10.1007/BF00833976

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00833976

Key Words

Search

Navigation