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Weakening of the hyperthermic effect of prostaglandin E2 by cholinomimetics, monoamines, and calcium ions

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on unanesthetized rats showed that the hyperthermic effect of prostaglandin E2 (PG-E2) is not prevented by aspirin, but can be considerably weakened by injection of arecoline, noradrenalin, serotonin, histamine, and CaCl2 into the lateral ventricles of the brain or by intraperitoneal injection of eserine. Experiments on unanesthetized rabbits showed that arecoline and nicotine have a similar action on PG-E2-induced hyperthermia if injected into the 3rd ventricle. Effects of serotonin and arecoline also were found when reinjected into the cerebral ventricles. In the center for heat loss there are evidently mechanisms which incorporate cholinergic neurons whose activity is not totally inhibited by prostaglandins.

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Authors
  1. V. N. Gurin
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  2. V. V. Tsaryuk
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  3. A. G. Tret'yakovich
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Gurin, V.N., Tsaryuk, V.V. & Tret'yakovich, A.G. Weakening of the hyperthermic effect of prostaglandin E2 by cholinomimetics, monoamines, and calcium ions. Bull Exp Biol Med 87, 151–154 (1979). https://doi.org/10.1007/BF00833975

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  • DOI: https://doi.org/10.1007/BF00833975

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