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The effect of chondroitin sulfate (chonsuridum) on collagen in vivo

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the effect of acid mucopolysaccharide chondroitinsulfate on the healing of wounds. A standard preparation (chonsuridum) was tested for electrophoretic mobility, for turbidity and hexoseamine content and by chromatographic separation on ion exchange resins. The preparation was found to stimulate regeneration in slowly healing wounds. The action of chondroitinsulfate was studied histochemically. Local (external) application stimulated cellular connective tissue regeneration and the synthesis of precollagen and collagen proteins. Ribonucleic acid plays an important part in this process. The best clinical results were obtained in treating slowly granulating wounds after surgical intervention, decubitus ulcers, trophic ulcers etc.

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Authors and Affiliations

  1. Central Institute of Traumatology and Orthopedics, USSR Ministry of Health, Moscow, USSR

    B. S. Kasavina, A. I. Rikhter, G. D. Zenkevich & A. A. Arenberg

  2. Department of Histology, Moscow Medical Institute of Stomatology, Moscow, USSR

    B. S. Kasavina, A. I. Rikhter, G. D. Zenkevich & A. A. Arenberg

Authors
  1. B. S. Kasavina
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  2. A. I. Rikhter
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  3. G. D. Zenkevich
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  4. A. A. Arenberg
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Deceased.

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Kasavina, B.S., Rikhter, A.I., Zenkevich, G.D. et al. The effect of chondroitin sulfate (chonsuridum) on collagen in vivo. Bull Exp Biol Med 51, 718–720 (1961). https://doi.org/10.1007/BF00833900

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  • DOI: https://doi.org/10.1007/BF00833900

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