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The effect of ionizing radiation on the content of free and bound acetylcholine in the liver and brain

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

In testing on leech dorsal muscle the authors determined the contents of free (conditionally) and bound acetylcholine (ACh) in the liver and brain tissues of rats both in normal conditions and following γ-ray irradiation in a dose of 800 r. As demonstrated, the content of free and bound ACh was several times greater in the brain than in the liver. Considerable individual variations were noted. In 2 hours after the irradiation the content of free ACh in the liver decreased to only traces. Its initial level was gradually restored by the 2nd post-irradiation day. The content of free ACh in the brain dropped too, although to a much lesser extent. The concentration of bound ACh remained rather stable in the brain of irradiated animals, whereas the range of its variations in the liver had somewhat increased.

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Authors
  1. N. N. Demin
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  2. N. V. Korneeva
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Demin, N.N., Korneeva, N.V. The effect of ionizing radiation on the content of free and bound acetylcholine in the liver and brain. Bull Exp Biol Med 51, 689–691 (1961). https://doi.org/10.1007/BF00833892

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  • DOI: https://doi.org/10.1007/BF00833892

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