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The Role of Typological Characteristics of Higher Nervous Activity in Rats in the Neurobiological Effects of Combined Exposure to an Antiorthostatic Suspension, γ-Rays, Protons, and Carbon 12C Ions

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Abstract

The study of the role of typological characteristics of higher nervous activity of rats in the neurobiological effects (rat behavior and its neurochemical mechanisms) of combined exposure to a 10-day antiorthostatic suspension, γ-, and high-energy proton and carbon ion (12C) irradiation demonstrated that the 12C ion irradiation caused more marked distortion of the ratio of orientation and exploratory behavior and passive defensive behavior/anxiety in rats of the excitable anxious emotional type. In the experiment with proton irradiation, the differences between typological groups were more smoothed out, though some parameters of passive defensive behavior in the rats of the experimental groups were also increased. These changes were accompanied by decreased monoamine metabolism in the prefrontal cortex.

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Funding

This work was supported by the Program of the Presidium of the Russian Academy of Sciences and by the Russian Foundation for Basic Research, project nos. 17-29-01002-ofi_m and 17-29-01005-ofi_m.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    A. S. Shtemberg, A. A. Perevezentsev, K. B. Lebedeva-Georgievskaya, O. V. Mitrofanova, V. S. Kudrin & A. S. Bazyan

  2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    A. S. Bazyan

Authors
  1. A. S. Shtemberg
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  2. A. A. Perevezentsev
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  3. K. B. Lebedeva-Georgievskaya
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  4. O. V. Mitrofanova
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  5. V. S. Kudrin
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  6. A. S. Bazyan
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Correspondence to A. S. Shtemberg.

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Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by E. Makeeva

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Shtemberg, A.S., Perevezentsev, A.A., Lebedeva-Georgievskaya, K.B. et al. The Role of Typological Characteristics of Higher Nervous Activity in Rats in the Neurobiological Effects of Combined Exposure to an Antiorthostatic Suspension, γ-Rays, Protons, and Carbon 12C Ions. Biol Bull Russ Acad Sci 47, 1507–1515 (2020). https://doi.org/10.1134/S1062359020110138

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