Abstract
Infection of an RES culture by toxoplasmas does not seriously disturb the vital activity of the cells and does not cause them to degenerate rapidly. Changes observed in the morphology of the host cells are evidently mainly the result of purely mechanical pressure of the vacuoles on the nucleus and cytoplasm, although extreme forms of disturbance of cell morphology are possibly associated with more severe injury. Complete “self-sterilization” of the cultures evidently does not take place for, despite a sharp decrease in the number of parasites, the possibility of reinfection of the culture by toxoplasmas in the later stages after initial infection cannot be ruled out.
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Akinshina, G.T., Zalkind, S.Y. Cytological study of transplantable line of pig embryonic kidney cells persistently infected with toxoplasmas. Bull Exp Biol Med 80, 1265–1267 (1975). https://doi.org/10.1007/BF00833181
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DOI: https://doi.org/10.1007/BF00833181