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Cytomorphological Changes in the Blood and Mesonephros of Goldfish Infected with Ligula (Digramma) interrupta (Cestoda: Pseudophyllidea)

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Abstract—

The cytomorphological composition of the blood and mesonephros of goldfish infected with Ligula interrupta has been studied under the conditions of the native range. A decrease in the total number of leukocytes and neutrophils in the blood at all stages of development and deregulation of the proliferation and differentiation of lymphoid, pseudo-eosinophilic, and pseudo-basophilic elements in the studied organs are established. Infiltration of neutrophilic mesonephros by low-differentiated forms is observed. It has been shown that, in this parasitic system, the partner relations cause the launch by L. interrupta of mechanisms that regulate the host immune response by inhibiting the acute inflammatory response and the development of mild chronic inflammation. B-cell activation in the immune response is accompanied by processes of cellular degeneration and immunosuppression, factors that are actively involved in cytotoxic reactions.

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ACKNOWLEDGMENTS

We are grateful to A.V. Elizov (Baikal Specialized Station for Control of Diseases in Fish and Other Hydrobionts, Republic of Buryatia), N.M. Pronin, and O.B. Zhepkholova (Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Sciences) for help in collecting the material.

Funding

This study was performed within the program of project no. АААА-А17-117011810039-4 and was supported by the Russian Foundation for Basic Research (project no. 19-04-00666).

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Authors and Affiliations

  1. Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Sciences, 670047, Ulan-Ude, Russia

    O. E. Mazur, I. A. Kutyrev & Zh. N. Dugarov

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  1. O. E. Mazur
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  2. I. A. Kutyrev
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  3. Zh. N. Dugarov
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Correspondence to O. E. Mazur.

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Translated by N. Ruban

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Mazur, O.E., Kutyrev, I.A. & Dugarov, Z.N. Cytomorphological Changes in the Blood and Mesonephros of Goldfish Infected with Ligula (Digramma) interrupta (Cestoda: Pseudophyllidea). Biol Bull Russ Acad Sci 47, 56–62 (2020). https://doi.org/10.1134/S1062359020010070

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  • DOI: https://doi.org/10.1134/S1062359020010070

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