Abstract
Experiments in vitro on rat liver mitochondria showed that morphine inhibits oxidation of substrates in the presence of ADP and reduces the rate of phosphorylation and the activity of dinitrophenol-stimulated ATPase. The inhibition constant for all these reactions is the same, namely 6.5 mM. Respiration of mitochondria in the presence of an uncoupling agent and also the activity of ATP synthetase and ATPase of the submitochondrial particles are not inhibited in the presence of morphine. It is postulated that morphine inhibits the transfer of adenine nucleotides across the mitochondrial membrane.
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Gegenava, G.P., Chistyakov, V.V. Effect of morphine in vitro on oxidative phosphorylation in rat liver mitochondria. Bull Exp Biol Med 80, 1218–1220 (1975). https://doi.org/10.1007/BF00833166
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DOI: https://doi.org/10.1007/BF00833166