Abstract
Muscle cells of the pulmonary artery have no spontaneous activity. Electrical stimulation of these cells leads to the formation of electronic potentials unaccompanied by any change in isometric contraction of a strip of the artery. Noradrenalin, in a concentration of 10−8 g/ml, causes depolarization of the muscle cell membrane by 5–7 mV and a marked increase in contraction of the muscle strip. Under these conditions, catelectronotonic depolarization was accompanied by contraction of the strip, but anelectrotonic hyperpolarization by its relaxation. Phentolamine, and α-adrenoblocker, prevents the noradrenalin effect, indicating a role of α-adrenoblockers in the mechanism of the excitatory action of noradrenalin on the smooth-muscle cells of the pulmonary artery.
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Gurkovskaya, A.V., Chaprina, L.P. Effect of noradrenalin on electrical and contractile properties of smooth-muscle cells of the pulmonary artery. Bull Exp Biol Med 80, 1147–1149 (1975). https://doi.org/10.1007/BF00833141
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DOI: https://doi.org/10.1007/BF00833141