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Changes in rhythm of liver enzyme activity in albino rats during chronic exposure to vinyl acetate

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In experiments on male albino rats in the course of observations lasting 5 months synchronized cyclic changes in the activity of liver aspartate-and alanine-aminotransferase activity took place. Prolonged continuous exposure of the animals to vinyl-acetate vapor in a concentration of 2.4 mg/m3 disturbed the rhythm of these fluctuations while maintaining the synchronization of the changes in enzyme activity. Higher concentrations of vinyl acetate (13.2 and 68 mg/m3), producing chronic poisoning, led to desynchronization of the fluctuations in liver transaminase activity. The possibility of using correlation analysis for determining the degree of synchronization of the activity of enzyme systems so as to evaluate the toxic action of poisons is discussed.

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Authors
  1. L. V. Tiunova
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  2. A. P. Rumyantsev
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Tiunova, L.V., Rumyantsev, A.P. Changes in rhythm of liver enzyme activity in albino rats during chronic exposure to vinyl acetate. Bull Exp Biol Med 79, 453–455 (1975). https://doi.org/10.1007/BF00832725

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  • DOI: https://doi.org/10.1007/BF00832725

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