Skip to main content
SpringerLink
Log in

Investigation of the thymus as a source of a humoral factor stimulating antibody formation

  • Microbiology and Immunobiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

By fractionation of calf thymus extract No. 1A, prepared by the method of Goldstein et al., on a column with Sephadex G-25 a fraction stimulating antibody formation in newborn animals was obtained. Tests of the activity of analogous fractions of extracts of calf tonsils, spleen, lymph glands, and liver suggested that the thymus is the sole source of a specific humoral factor stimulating antibody formation which may accumulate in peripheral lymphoid structures. The low activity of tonsillar extracts does not confirm the hypothetical role of the tonsil as the central organ of immunity, corresponding to the bursa of Fabricius.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. É. V. Gyulling, V. M. Kavsan, O. F. Mel'nikov et al., Zh. Ush. Nos. Gorl. Bol., No. 6 25 (1971).

    Google Scholar 

  2. V. M. Kavsan and I. S. Nikol'skii, in: Immunology [in Russian], No, 6, Kiev (1973), p. 16.

  3. I. N. Kendysh, Uspekhi Sovr. Biol.,73, 342 (1972).

    Google Scholar 

  4. D. A. Kostadinov and B. B. Fuks, Vestn. Akad. Med. Nauk SSSR, No. 5, 88 (1973).

    Google Scholar 

  5. I. S. Nikol'skii, Zh. Ush. Nos. Gorl. Bol. No. 6, 3, (1973).

    Google Scholar 

  6. I. A. Oivin, Pat. Fiziol., No. 1, 76 (1960).

    Google Scholar 

  7. A. Ya. Fridenshtein and I. L. Cherkov, The Cellular Basis of Immunity [in Russian], Moscow (1969).

  8. J. F. Bach, Rev. Europ. Etud. Clin. Biol.,17, 545 (1972).

    Google Scholar 

  9. N. A. Bezssonoff, and J. Comsa, Ann. Endocrinol. (Paris),19, 222 (1958).

    Google Scholar 

  10. P. Falk, Arch. Ohr.-Nas.-Kehlk.-Heilk.,176, 713 (1960).

    Google Scholar 

  11. A. L. Goldstein, F. D. Slater, and A. White, Proc. Nat. Acad. Sci. U.S.A.,56, 1010 (1966).

    Google Scholar 

  12. A. L. Goldstein, G. Asanuma, J. R. Battisto, et al., J. Immunol.,104, 359 (1970).

    Google Scholar 

  13. R. A. Good and A. A. Gabrialsen, in: Transplantation of Organs and Tissues in Man [in Russian], Moscow (1973), p. 422.

  14. T. J. Hand, W. S. Ceglowski H. Friedman et al., J. Immunol.,105, 442 (1970).

    Google Scholar 

  15. N. Jerne and A. Nordin, Science,140, 405 (1963).

    Google Scholar 

  16. O. Lowry, N. Rosebrough, A. Farr, et al., J. Biol. Chem.,193, 265 (1951).

    Google Scholar 

  17. J. Miller Austral. J. Sci.,32, 87 (1969).

    Google Scholar 

  18. J. Miller and D. Osoba, Physiol. Rev.,47, 437 (1967).

    Google Scholar 

  19. D. Osoba, Proc. Soc. Exp. Biol. (New York),127, 418 (1968).

    Google Scholar 

  20. M. Small and N. Trainin, Nature,216, 377 (1967).

    Google Scholar 

Download references

Authors
  1. É. V. Gyulling
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. S. Nikol'skii
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gyulling, É.V., Nikol'skii, I.S. Investigation of the thymus as a source of a humoral factor stimulating antibody formation. Bull Exp Biol Med 79, 433–435 (1975). https://doi.org/10.1007/BF00832719

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00832719

Key Words

Search

Navigation