Abstract
The effect of the principal anti-inflammatory drugs in current use (prednisolone, acetylsalicylic acid, rheopyrine, chloroquine, and indomethacin) on the thermal effect of human peripheral red blood cells was studied. Only chloroquine was found to inhibit this effect significantly. This fact indicates that chloroquine inhibits energy production during glycolysis and this can be regarded as one of the factors in the therapeutic action of this substance.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
Ya. A. Sigidin, in: Current Problems in Rheumatology [in Russian], Moscow (1967), p. 20.
M. Whitehouse, J. Pharm. Pharmacol.,15, 556 (1963).
M. Whitehouse, Acta Rheum. Scand., Suppl. 8, 5 (1964).
M. Whitehouse, in: Nonsteroidal Anti-Inflammatory Drugs, Amsterdam (1965), p. 21.
A. Sisini et al., Minerva Med.,55, 1789 (1964).
E. M. Glenn et al., Rec. Progr. Hormone Res.,19, 107 (1963).
E. Racker, Mechanisms in Bioenergetics, Academic Press (1965).
Rights and permissions
About this article
Cite this article
Sigidin, Y.A., Taratuta, O.V. Effect of anti-inflammatory agents on heat production in red blood cells. Bull Exp Biol Med 79, 425–426 (1975). https://doi.org/10.1007/BF00832716
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00832716