Abstract
In experiments on rats, after intraperitoneal injection of theophylline the content of oxidized forms of pyridine nucleotides (NAD+NADP) was reduced by 19.4%, the level of the reduced forms (NAD·H2+NADP·H2) showed a tendency to decrease, and the total content of nicotinamide coenzymes was significantly reduced. After administration of caffeine the content of NAD+NADP and the total pyridine nucleotides showed a tendency to decrease. Theobromine had no significant effect on these parameters. The action of catecholamines and methylxanthines was compared. Isoproternol (exciting β-adrenergic receptors) lowered the NAD+NADP content, but adrenalin (25 μg/kg) increased the content of both oxidized (by 24%) and reduced (48%) forms of pyridine nucleotides. An increase in the dose of adrenalin (1000 μg/kg) led to a decrease in the level of oxidized forms (by 22.2%) and of the total nicotinamide coenzymes (by 18%).
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Frantsuzova, S.B. Effect of methylxanthines (theophylline, theobromine, caffeine) and catecholamines on nicotinamide coenzyme content in the rat myocardium. Bull Exp Biol Med 79, 418–420 (1975). https://doi.org/10.1007/BF00832714
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DOI: https://doi.org/10.1007/BF00832714