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Effect of neuroleptics of the phenothiazine series on firing rate and ultrastructure of rabbit cortical neurons

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In experiments on rabbits chlorpromazine, in a dose of 5 mg/kg, caused deaggregation of the polysomes, dilatation of the cisterns of the endoplasmic reticulum, hypertrophy of the Golgi apparatus, and swelling of the mitochondria in most cortical neurons. These ultrastructural changes were accompanied by inhibition of unit activity. Trifluoperazine, in the same dose, unlike chlorpromazine led to condensation of the mitochondrial matrix of some neurons, with a corresponding increase in the firing rate of 28% of cortical cells. This correlation between changes in unit activity and neuronal ultrastructure is examined in connection with differences in the spectrum of psychotropic activity of the two phenothiazine derivatives with neuroleptic properties.

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Authors
  1. A. V. Nemtsov
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  2. G. R. Dubinskaya
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Nemtsov, A.V., Dubinskaya, G.R. Effect of neuroleptics of the phenothiazine series on firing rate and ultrastructure of rabbit cortical neurons. Bull Exp Biol Med 79, 414–417 (1975). https://doi.org/10.1007/BF00832713

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  • DOI: https://doi.org/10.1007/BF00832713

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