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Rosette formation in a system of adoptive transfer of cell populations from donors with an altered serotonin level

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The formation of the primary immune response to injection of cells of various immunocompetent organs of nonimmune intact donors and also of animals receiving serotonin into sublethally irradiated recipients was studied. Considerable changes were found in the development of the immune response, mainly on account of IgM-rosette-forming cells, both after transfer of spleen cells alone and after combined injection of spleen cells with bone marrow and thymus cells from the same donors. The results are evidence of a possible effect of serotonin on changes in the relative proportions and migration of T- and B-cells in different organs and also on the action of serotonin on T-and B-suppressor cells.

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Authors
  1. L. V. Devoino
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  2. M. A. Cheido
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  3. G. V. Idova
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Devoino, L.V., Cheido, M.A. & Idova, G.V. Rosette formation in a system of adoptive transfer of cell populations from donors with an altered serotonin level. Bull Exp Biol Med 88, 1438–1441 (1979). https://doi.org/10.1007/BF00830355

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  • DOI: https://doi.org/10.1007/BF00830355

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