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Chemie der Pleuromutiline, 10. Mitt.: 1,2-Transposition der Carbonylfunktion im Cyclopentanonteil des tricyclischen Gerüstes

Chemistry of pleuromutilins, 10. Comm. 1,2-transposition of the carbonylfunction in the cyclopentanone moiety of the tricyclic skeleton

  • Organische Chemie Und Biochemie
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Abstract

2-Hydroxy-19,20-dihydropleuromutilin (10) undergoes a stereospecific ketolisomerisation when treated with base under phase/transfer conditions (11, 12). The subsequent reductive elimination of the 3-acetoxygroup afforded mutilin with a 1,2-transposed ketofunction (13).

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Authors and Affiliations

  1. Sandoz-Forschungsinstitut, A-1235, Wien, Österreich

    Heinz Berner, Hermann Vyplel, Gerhard Schulz & Gernot Fischer

Authors
  1. Heinz Berner
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  2. Hermann Vyplel
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  3. Gerhard Schulz
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  4. Gernot Fischer
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Berner, H., Vyplel, H., Schulz, G. et al. Chemie der Pleuromutiline, 10. Mitt.: 1,2-Transposition der Carbonylfunktion im Cyclopentanonteil des tricyclischen Gerüstes. Monatsh Chem 116, 1165–1176 (1985). https://doi.org/10.1007/BF00811250

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  • DOI: https://doi.org/10.1007/BF00811250

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