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3-[2-(3,5-dimethylpyrazolyl)] succinic anhydride: Synthone for the synthesis of some heterocycles with potential pharmaceutical activity

3-[2-(3,5-Dimethylpyrazolyl)]-succinanhydrid, ein Synthon für die Synthese einiger Heterocyclen mit potentieller pharmazeutisch nutzbarer Aktivität

  • Organische Chemie Und Biochemie
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Summary

Aminolysis of 3-[2-(3,5-dimethylpyrazolyl)] succinic anhydride (1) leads to5. Hydrazine hydrate reacts with1a to give 4-(3,5-dimethylpyrazolyl)-1,2,4,5-tetrahydro-3,6-pyridazindione. The structures were confirmed by IR, MS,1H and13C NMR.

Zusammenfassung

Die Aminolyse von 3-[2-(3,5-Dimethylpyrazolyl)]-succinanhydrid (1) führt zu5. Hydrazinhydrat reagiert mit1a zu 4-(3,5-Dimethylpyrazolyl)-1,2,4,5-tetrahydro-3,6-pyridazindion. Die Strukturen wurden mittels IR, MS,1H-NMR und13C-NMR überprüft.

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References

  1. Oldham K. A. (1960) Essentials of pharmacology. Lippincott, Philadelphia, 119

    Google Scholar 

  2. Metwally M. A., Afsah E. M. (1987) J. Prakt. Chem.329(4: 563

    Google Scholar 

  3. Nada A. A., Abd El-Halim M. S., Gad W. A., Runsink J. (1983) Egypt J. Chem.26: 241

    Google Scholar 

  4. Abd El-Halim M. S., Nada A. A., Gad W. A. (1984) Fifth International Conference on Organic Synthesis, Freiburg/Br., W. Germany (Conference proceedings 139)

  5. Ballamy R. G., Songested J. (1967) J. Am. Chem. Soc.89: 1827

    Google Scholar 

  6. Cotter J. L. (1964) J. Chem. Soc. 5477

  7. Cotter J. L. (1965) J. Chem. Soc. 5742

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Authors and Affiliations

  1. Chemistry Department, Faculty of Engineering, Ain Shamis University, Cairo, Egypt

    M. S. Abd El Halim

  2. National Research Center, Dokki, Cairo, Egypt

    A. Nada & W. A. Gad

Authors
  1. M. S. Abd El Halim
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  2. A. Nada
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  3. W. A. Gad
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Abd El Halim, M.S., Nada, A. & Gad, W.A. 3-[2-(3,5-dimethylpyrazolyl)] succinic anhydride: Synthone for the synthesis of some heterocycles with potential pharmaceutical activity. Monatsh Chem 125, 1437–1442 (1994). https://doi.org/10.1007/BF00811093

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  • DOI: https://doi.org/10.1007/BF00811093

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