Abstract
A new synthesis of the indole system has been achieved by chclodehydrogenation of amino phenylmalonate heterocycles. Thus, the 4-amino coumarins1 a,b or the 4-amino-2-quinolones1 c–g are converted to the indoles2 with palladium on charcoal in boiling diphenyl ether. The reaction of the aminocompounds1 with diphenyl carbonate yields the fused polycyclic isoquinolones4.
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Stadlbauer, W., Kappe, T. Synthese von Indolen und Isochinolonen aus Phenylmalonylheterocyclen. Monatsh Chem 115, 467–475 (1984). https://doi.org/10.1007/BF00810008
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DOI: https://doi.org/10.1007/BF00810008