Abstract
Morphological changes in the organs of immunogenesis (thymus, lymph glands, spleen) were studied and the RNA content of these organs determined biochemically in 92 rats during growth of a transplanted intracerebral glioblastoma multiforme (strain No. 101/12). The response of the lymphoreticular organs was shown to depend on the stage of the disease. On the 6th day after transplantation of the tumor, for instance, activation of the reticuloendothelial part of the thymus, hyperplasia of the lymphoid follicles in the lymph glands, and activation of nucleic acid synthesis were observed, whereas in animals with a developing tumor death of the lymphoic elements and a decrease in RNA sysnthesis were found. Morphological investigation of the spleen showed a gradual reduction in its cell population.
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Bezuglova, T.V., Yurkiv, V.A. Morphological and biochemical investigation of the organs of immunogenesis during intracerebral growth of transplanted glioblastoma multiforme in albino rats. Bull Exp Biol Med 80, 808–810 (1975). https://doi.org/10.1007/BF00809898
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DOI: https://doi.org/10.1007/BF00809898