Skip to main content
SpringerLink
Log in

Experimental study of the modifying action of darkness on growth of mammary gland carcinoma and efficacy of hormone therapy

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of different conditions of illumination on the properties of a transplantable rat mammary-gland carcinoma (RMK-1) and on the efficacy of its hormone therapy was studied. In darkness the percentage of successful takes was reduced, the rate of growth of the RMK-1 tumor was slowed, and the efficacy of estrogen therapy of the mammary-gland carcinoma was increased considerably. It is suggested that the increased efficacy of treatment of the RMK-1 tumor in darkness can be attributed to changes in functional activity of the hypothalamic-pituitary system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. B. V. Aleshin, Histophysiology of the Hypothalamic-Pituitary System [in Russian], Moscow (1971).

  2. M. G. Goncharova, “The follicle-stimulating function of the pituitary during estrogen therapy of mammary-gland carcinoma,” Author's Abstract of Candidate's Dissertation, Moscow (1970).

  3. V. P. Konoplev and N. D. Lagova, Byull. Éksperim. Biol i Med., No. 7, 79 (1960).

    Google Scholar 

  4. V. P. Konoplev and N. D. Lagova, Byull. Éksperim. Biol. i Med., No. 4, 91 (1963).

    Google Scholar 

  5. A. K. Kuralasov, in: Proceedings of the First All-Union Conference on Chemotherapy of Malignant Tumors [in Russian], Riga (1968), p. 437.

  6. A. K. Kuralasov, Izvest. Akad. Nauk Kazakh SSR Seriya Biol., No. 1, 79 (1970).

    Google Scholar 

  7. N. D. Lagova, “Experimental groundwork of hormone therapy of mammary-gland carcinoma,” Author's Abstract of Doctoral Dissertation, Moscow (1973).

  8. N. I. Lazarev, Theoretical Basis of Prevention and Treatment of Dyshormonal Tumors [in Russian], Moscow (1963).

  9. N. I. Lazarev (Editor), Hormone Therapy of Malignant Tumors [in Russian], Moscow (1968).

  10. L. F. Larionov, Chemotherapy of Malignant Tumors [in Russian], Moscow (1962).

  11. I. O. Smirnova, Probl. Éndokrinol., No. 5, 87 (1969).

    Google Scholar 

  12. V. M. Fiske et al., Endocrinology,64, 175 (1959).

    Google Scholar 

  13. R. Schreck, Am. J. Cancer,24, 807 (1935).

    Google Scholar 

Download references

Authors
  1. A. K. Kuralasov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuralasov, A.K. Experimental study of the modifying action of darkness on growth of mammary gland carcinoma and efficacy of hormone therapy. Bull Exp Biol Med 80, 805–807 (1975). https://doi.org/10.1007/BF00809897

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00809897

Key Words

Search

Navigation