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Conformational behaviour ofZ-Pro-(thr)Ox-OMe in solution

Konformationsverhalten vonZ-Pro-(thr)Ox-OMe in Lösung

  • Organische Chemie Und Biochemie
  • Published:
Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

The dipeptideZ-Pro-(thr)Ox-OMe was studied with respect to its conformation in solution using NMR spectroscopic methods. It is shown that two conformers exist at room temperature which are related to each other by acis-trans—isomerization of theZ-Pro—peptide bond. The free energy of activation of the process is estimated.

Zusammenfassung

Das DipeptidZ-Pro-(thr)Ox-OMe wurde mittels Kernresonanzspektroskopie im Hinblick auf seine Konformation in Lösung untersucht. Die erhaltenen Daten weisen auf das Vorliegen von zwei Konformeren bei Raumtemperatur hin, die durch einecis-trans-Isomerierung derZ-Pro-Peptidbindung ineinander übergehen. Die freie Aktivierungsenergie der Konformationsumwandlung konnte abgeschätzt werden.

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Authors and Affiliations

  1. Laboratorium für Organische Chemie I, Universität Bayreuth, D-8580, Bayreuth, Federal Republic of Germany

    Ernst Haslinger

  2. Institut für Organische Chemie, Universität Wien, A-1090, Wien, Austria

    Hermann Kalchhauser

Authors
  1. Ernst Haslinger
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  2. Hermann Kalchhauser
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Additional information

Dedicated to Prof. Dr.A. Neckel on the occasion of his 60th birthday.

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Haslinger, E., Kalchhauser, H. Conformational behaviour ofZ-Pro-(thr)Ox-OMe in solution. Monatsh Chem 118, 607–615 (1987). https://doi.org/10.1007/BF00809672

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  • DOI: https://doi.org/10.1007/BF00809672

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