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Synthesis of long alkyl chain mono-and di-N-substituted 4-amino-N-methylphthalimides. Comparison of N-alkylation methods

Synthese langkettig mono- und di-N-substituierter 4-Amino-N-methylphthalimide. Ein Vergleich von N-Alkylierungsmethoden

  • Organische Chemie Und Biochemie
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Summary

4-Amino-N-methylphthalimide,1, was N-alkylated with the respectiven-alkyl sulfonates and halides. In the former case, the di-derivative4 was favored, while in the latter case, under phase transfer catalysis, the mono-derivative3 was predominant.

Zusammenfassung

4-Amino-N-methylphthalimide (1) wurden mit den entsprechendenn-Alkylsulfonaten und -halogeniden N-alkyliert. Im ersten Fall wurden die Di-Derivate4 bevorzugt gebildet, im zweiten Fall waren unter Phasentransferkatalyse die Mono-Produkte3 vorherrschend.

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Authors and Affiliations

  1. Institute of Physical Chemistry, N.R.C. “Democritos”, GR-15310 Aghia Paraskevi, Attiki, Greece

    David S. Amarilio & Fannie S. Varveri

Authors
  1. David S. Amarilio
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  2. Fannie S. Varveri
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Amarilio, D.S., Varveri, F.S. Synthesis of long alkyl chain mono-and di-N-substituted 4-amino-N-methylphthalimides. Comparison of N-alkylation methods. Monatsh Chem 122, 139–144 (1991). https://doi.org/10.1007/BF00809358

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  • DOI: https://doi.org/10.1007/BF00809358

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